Cardiothoracic & vascular anesthesia
Peak Gradients and Left Ventricular Outflow Tract Area in Hypertrophic Obstructive Cardiomyopathy:A 3-Dimensional Echocardiography Study
Authors' conclusion
Intraoperative 3D echocardiography enables precise, real-time quantification of LVOT obstruction in HOCM and enhances intraoperative assessment during septal myectomy.
Study context
- Population
- Patients undergoing septal myectomy for symptomatic hypertrophic obstructive cardiomyopathy (HOCM) at a single tertiary university hospital, February 2021–December 2024
- Participants
- 36 patients
- Exposure
- Left ventricular outflow tract (LVOT) area vs Doppler peak gradients, before vs after septal myectomy
- Outcome
- Correlation between LVOT area and peak gradient
Methodological detailssingle-centre, Real-time 3D echocardiography during pre-bypass planning; dobutamine stress echocardiography before and after CPB
- Single-centre
- Real-time 3D echocardiography during pre-bypass planning; dobutamine stress echocardiography before and after CPB
Main finding
As reported in the abstract
Preoperative correlation, r (p < 0.001)
−0.64
Postoperative correlation, r (p = 0.018)
−0.30
Observational data: associations, not effects.
Further findings
LVOT area reduction with stress augmentation, preoperative
- Median reduction in LVOT area at peak gradient levels
- 58.2%
Peak gradients and LVOT area after myectomy
- Peak gradients decreased significantly (median, mmHg; p < 0.001)
- 11.5-24.0
- Reduction in LVOT area
- 16.9%
Elevated peak gradients without demonstrable LVOT obstruction, postoperative
- Proportion of patients
- 22%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Peak Gradients and Left Ventricular Outflow Tract Area in Hypertrophic Obstructive Cardiomyopathy:A 3-Dimensional Echocardiography Study. J Cardiothorac Vasc Anesth. Published 11 January 2026. doi:10.
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