Cardiothoracic & vascular anesthesia
Peak systolic myocardial velocity in patients undergoing surgical aortic valve replacement for severe aortic stenosis: prognostic value and natural course
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.60 95% CI 1.04–2.48Authors' conclusion
Pre-S' < 5.4 cm/s was found to be associated with an increased long-term all-cause mortality.
Study context
- Population
- Patients undergoing surgical aortic valve replacement for severe aortic stenosis (AS), January 2006 to December 2018analysed
- Participants
- 905 patients
- Exposure
- Preoperative S' <5.4 cm/s vs ≥5.4 cm/s
- Outcome
- Postoperative long-term all-cause mortality
Methodological detailsretrospective observational
- Retrospective observational
Main finding
All-cause mortality · median follow-up 5.2 years
Hazard ratio
1.60
95% CI 1.04–2.48
P = 0.032
By group
pre-S'LOW vs pre-S'HIGH
HR 1.60 (95% CI 1.04–2.48); P = 0.032
As reported in the abstract
Observational data: associations, not effects.
Further findings
Trajectory of postoperative S' (post-S')
- Significantly different trajectories between groups: in pre-S'LOW post-S' increased within 6 months then gradually decreased; in pre-S'HIGH slowly decreased up to 5 years then plateaued
- P < 0.001
- Difference in pre-S' level maintained over time, consistent in adjusted analysis
Original publication
Peak systolic myocardial velocity in patients undergoing surgical aortic valve replacement for severe aortic stenosis: prognostic value and natural course. J Clin Monit Comput. Published 25 July 2022. doi:10.
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