Hemodynamics, fluids & transfusion
Performance of Hemochron ACT-LR and ACT+ Test Cuvettes in Monitoring Low to Moderate Heparin Concentrations: An In Vitro Study
Main finding · Agreement and reliabilityResult — go to the resultbias 52 celite seconds 95% CI 48–56Authors' conclusion
The performance of ACT+ is equal to that of ACT-LR up to a concentration of 0.5 IU/mL, above which ACT+ is superior to ACT-LR, questioning the rationale for a specific low-range test. However, there is a significant bias between ACT-LR and ACT+ measurements that needs to be considered if switching from one test to the other.
Study context
- Population
- Blood of healthy adult volunteers spiked with unfractionated heparin to 0, 0.5, 1.0, 1.5, 2.0 and 2.5 IU/mL; tertiary care university hospital
- Participants
- 720 ACT tests
- Comparison
- Hemochron ACT-LR vs ACT+ test cuvettes
- ACT-LRn = 360
- ACT+n = 360reference
- Outcome
- Agreement and reliability
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
bias
52 celite seconds
95% CI 48–56
Further findings
- Tests above upper measurement range — ACT-LR
- 11%
- Tests above upper measurement range — All ACT+ tests yielded a result
- 360
- Tests above upper measurement range — ACT-LR tests above range from the 120 measurements at heparin ≥2.0 IU/mL
- 36
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Performance of Hemochron ACT-LR and ACT+ Test Cuvettes in Monitoring Low to Moderate Heparin Concentrations: An In Vitro Study. J Cardiothorac Vasc Anesth. Published 4 December 2024. doi:10.
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