Cardiothoracic & vascular anesthesia
Perioperative Acute Renal Injury: Revisiting Pathophysiology
Authors' conclusion
Patients developing postoperative acute renal dysfunction had significantly higher urinary NGAL concentrations early after cardiac surgery.
Study context
- Population
- Adult cardiac surgical patients
- Participants
- 81 patients
- Exposure
- Patients with vs without postoperative acute renal dysfunction
- Acute renal dysfunctionn = 16
- Outcome
- Postoperative urinary NGAL concentration (quantitative immunoblotting)
Main finding
As reported in the abstract
Urinary NGAL concentration · 1 h after surgery
P < 0.01
Observational data: associations, not effects.
Further findings
Incidence of postoperative acute renal dysfunction
- Patients developing postoperative acute renal dysfunction
- 16 of 81 (20%)
Urinary NGAL concentration · 3 and 18 h after surgery
- Continued to increase and remained significantly higher in patients with acute renal dysfunction; decreased rapidly in patients without
Original publication
Perioperative Acute Renal Injury: Revisiting Pathophysiology. Anesthesiology. Published 10 May 2024. doi:10.
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