Perioperative medicine & outcomes
Perioperative Dexamethasone in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials
Pooled result · Surgical site infectionResult — go to the resultLOR −0.10 95% CI −0.64 to 0.44Authors' conclusion
Current evidence suggests perioperative dexamethasone may be given to diabetic patients without increasing the risk of infectious complications.
Study context
- Population
- Diabetic patients undergoing surgery
- Participants
- 2,592 patients · 16 studies
- Comparison
- Short-course perioperative dexamethasone vs placebo
- Dexamethasonen = 1,184
- Placebon = 1,160reference
- Outcome
- Surgical site infection
Methodological detailsplacebo-controlled trials, random effects, inverse variance, subgroup analyses of diabetic patients, 5 of 16 studies analysed quantitatively
- Placebo-controlled trials
- Random effects
- Inverse variance
- Subgroup analyses of diabetic patients
- 5 of 16 studies analysed quantitatively
Pooled result
As reported in the abstract
LOR
−0.10
95% CI −0.64 to 0.44
Further pooled results
| Outcome | LOR (95% CI) |
|---|---|
| Composite of adverse eventsSignificantly reduced | −0.33 (−0.62 to −0.05) |
All clinical outcomes (qualitative analysis)
- Noninferior to superior results across all clinical outcomes
Safety
| Outcome | LOR (95% CI) |
|---|---|
| Composite of adverse eventsSignificantly reduced | −0.33 (−0.62 to −0.05) |
Original publication
Perioperative Dexamethasone in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials. Anesth Analg. Published 16 August 2024. doi:10.
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