Cardiothoracic & vascular anesthesia
Perioperative Gelatin Use Is Associated With Increased Complication Rates and Does Not Prevent Postoperative Fluid Overload in Patients Undergoing Elective Cardiac Surgery
Authors' conclusion
Gelatin administration versus crystalloid fluid management showed a significant association with a higher rate of FO and an increased risk for early postoperative AKI in a dose-dependent manner.
Study context
- Population
- Patients scheduled for cardiac surgery, single-center tertiary university setting191 matched pairs
- Participants
- 191 vs 191
- Exposure
- Gelatin vs Crystalloid
- Gelatinn = 191
- Crystalloidn = 191reference
- Outcome
- Frequency of fluid overload (FO) and hemodynamic stability (vasoactive-inotropic score)
Methodological detailspropensity-score matched, single-centre
- Propensity-score matched
- Single-centre
Main finding
As reported in the abstract
Postoperative FO
P = 0.006
Observational data: associations, not effects.
Further findings
30-day mortality and 3-year survival
- Similar in the groups
Safety
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Early postoperative AKI | 1.982 (1.051–3.736) | P = 0.035 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Early postoperative acute kidney injury (AKI)
- Dose-dependent relationship between gelatin infusion and AKI
Postoperative complications (blood loss, AKI, new-onset postoperative AF)
- Higher rate with gelatin
Original publication
Perioperative Gelatin Use Is Associated With Increased Complication Rates and Does Not Prevent Postoperative Fluid Overload in Patients Undergoing Elective Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 5 December 2022. doi:10.
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