Cardiothoracic & vascular anaesthesia
Perioperative mechanical ventilation strategies in adult cardiac surgery with cardiopulmonary bypass: a meta-analysis of randomised controlled trials
Pooled result · All-cause mortality (postoperative noninvasive respiratory support)Result — go to the resultRelative risk 0.60 95% CI 0.34–1.08Authors' conclusion
Ventilation during cardiopulmonary bypass significantly reduced postoperative pulmonary complications. Postoperative noninvasive respiratory support showed a non-significant trend toward improved survival and remains hypothesis-generating.
Study context
- Population
- Adults undergoing cardiac surgery requiring CPB39 of 105 RCTs meta-analysed
- Comparison
- Noninvasive respiratory support vs Control
- Noninvasive respiratory supportn = 414
- Controln = 377reference
- Outcome
- All-cause mortality
Pooled result
As reported in the abstract
All-cause mortality (postoperative noninvasive respiratory support)
Relative risk
0.60
95% CI 0.34–1.08
P = 0.09
Events by group
Noninvasive respiratory support vs Control
RR 0.60 (95% CI 0.34–1.08); P = 0.09
Further pooled results
PPCs (ventilation during CPB)
| RR (95% CI) | P value | ||
|---|---|---|---|
| Ventilation during CPBI2=0%, 15 studies | 0.87 (0.79–0.96) | P = 0.005 | |
| 0.512Relative risk (log scale) |
Primary and secondary outcomes (pressure- vs volume-controlled; adaptive support vs conventional ventilation)
- Pressure-controlled vs volume-controlled ventilation during surgery and adaptive support vs conventional ventilation postoperatively not associated with improvements in primary or secondary outcomes
Original publication
Perioperative mechanical ventilation strategies in adult cardiac surgery with cardiopulmonary bypass: a meta-analysis of randomised controlled trials. Br J Anaesth. Published 27 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →