Pharmacokinetics of propofol in severely obese surgical patients
Authors' conclusion
We have developed a new PK model of propofol that is suitable for all adult weight classes.
Study context
- Population
- Adults (19–60 years, BMI 21.6–67.3 kg/m²) scheduled for laparoscopic cholecystectomy or bariatric surgery; 21 with BMI above 50 kg/m²474 serum samples
- Participants
- 69 adults
- Outcome
- PK model of propofol spanning normal-weight to very obese patients
Methodological detailsnon-linear mixed-effects modelling, randomised block sampling, arterial sampling over 24 h, Induction: propofol 2 mg/kg adjusted body weight over 2 min, then 6 mg/kg/h adjusted body weight over 30 min; maintenance with sevoflurane; remifentanil per clinical need
- Non-linear mixed-effects modelling
- Randomised block sampling
- Arterial sampling over 24 h
- Induction: propofol 2 mg/kg adjusted body weight over 2 min, then 6 mg/kg/h adjusted body weight over 30 min; maintenance with sevoflurane; remifentanil per clinical need
Main finding
As reported in the abstract
Final population PK model
Fixed allometric exponent applied to all clearance parameters improved model performance
0.75
Accuracy (post-hoc performance evaluation)
1.4%
Precision (post-hoc performance evaluation)
21.7%
Original publication
Pharmacokinetics of propofol in severely obese surgical patients. Acta Anaesthesiol Scand. Published 13 March 2024. doi:10.
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