Cardiothoracic & vascular anesthesia
Pharmacokinetics and Pharmacodynamics of Analgesic and Anesthetic Drugs in Patients During Cardiac Surgery With Cardiopulmonary Bypass: A Narrative Review
Authors' conclusion
In conclusion, dosing inaccuracies resulting in adverse events in on-pump cardiac surgery underscore the importance of understanding the pharmacokinetics and -dynamics of anesthetic and analgesic drugs during CPB.
Study context
- Population
- Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB)articles included of 197
- Participants
- 22 patients
- Outcome
- Effects of CPB on PK/PD of anesthetics and analgesics
Main finding
As reported in the abstract
Fentanyl and sufentanil plasma concentrations decrease on average at CPB initiation (increased volume of distribution), then increase during CPB
25%
Sufentanil increase post-CPB
almost 50%
Original publication
Pharmacokinetics and Pharmacodynamics of Analgesic and Anesthetic Drugs in Patients During Cardiac Surgery With Cardiopulmonary Bypass: A Narrative Review. Anesth Analg. Published 16 May 2025. doi:10.
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