Phosphodiesterase 3 inhibitors do not influence lactate kinetics and clinical outcomes in patients with septic shock: A multicentre cohort study
Authors' conclusion
No association was found between the administration of PDE3i and lactate kinetics, resolution of organ failure, ICU or hospital LOS or hospital mortality.
Study context
- Population
- Patients with septic shock and persistently elevated lactate (two arterial lactate ≥4 mmol/L at least 4 h apart)
- Participants
- 229 patients · 10 hospitals
- Exposure
- PDE3 inhibitors vs no PDE3 inhibitors
- PDE3in = 123
- Outcome
- Lactate kinetics (area between actual lactate concentrations and 2.2 mmol/L, AUClact2.2)
- Follow-up
- Three days
Methodological detailsmulticentre, propensity-score matched
- Multicentre
- Propensity-score matched
Main finding
As reported in the abstract
AUClact2.2
- Adding PDE3i as a cofactor to the multivariate model (R2 = 0.57) did not affect R2
- No differences in AUClact2.2 between treatment groups in propensity-matched analyses (60 vs 60; 30 vs 30)
- Propensity matched
Observational data: associations, not effects.
Further findings
SOFA scores, ICU and hospital length of stay (LOS), hospital mortality
- No differences between treatment groups
Original publication
Phosphodiesterase 3 inhibitors do not influence lactate kinetics and clinical outcomes in patients with septic shock: A multicentre cohort study. J Crit Care. Published 7 May 2024. doi:10.
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