Respiratory failure & ventilation
Physiologic Comparison of Airway Pressure Release Ventilation and Low Tidal Volume Ventilation in ARDS: A Randomized Controlled Trial
Authors' conclusion
APRV, as compared with LTV ventilation, could recruit dorsal region, reduce dorsal shunt, increase dorsal V˙/Q˙ matching, and improve ventilation homogeneity of the lungs, leading to better gas exchange and respiratory system static compliance in patients with moderate to severe ARDS.
Study context
- Population
- Patients with moderate to severe ARDS receiving controlled mandatory ventilation
- Participants
- 40 patients
- Comparison
- Airway pressure release ventilation (APRV) vs low tidal volume (LTV) ventilation
- APRVn = 20
- LTVn = 20reference
- Primary endpoint
- Lung V˙/Q˙ matching and ventilation homogeneity (electrical impedance tomography (EIT))
- Follow-up
- 24 hours
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Dorsal ventilation change, median
10.82% [IQR 2.62%-13.74%] vs 0.12% [IQR −2.81% to 4.76%]
P = 0.017
APRV
Dorsal shunt change, median
−4.67% [IQR −6.83% to 0.59%] vs 1.73% [IQR −0.95% to 5.53%]
P = 0.008
APRV
Dorsal V˙/Q˙ matching change, median
4.13% [IQR −0.26% to 10.47%] vs −3.29% [IQR −5.05% to 2.81%]
P = 0.026
APRV
- No difference in ventral dead space
- P = 0.903
Further findings
Gas exchange and respiratory mechanics · 24 hours
- Significantly higher PaO2/FiO2, higher static compliance and lower PaCO2 with APRV vs LTV
CO
- Comparable in both groups
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →