Hemodynamics, fluids & transfusion
Physiological and linical ffects of ifferent nfusion ates of ntravenous luids for olume xpansion: A coping eview
Authors' conclusion
In this scoping review, most studies showed that slower intravenous infusion rates result in a more efficient intravascular expansion, with a longer effect, and less edema than faster rates. Effects on clinical outcomes were inconsistent.
Study context
- Population
- Animals, healthy subjects, critically ill and perioperative patients of all ages7 animal, 11 clinical, 3 volunteer studies
- Comparison
- Slower vs faster IV fluid infusion rates for volume expansion
- Outcome
- Physiological and clinical effects
Methodological detailsSearched PubMed, EMBASE and Cochrane CENTRAL, 7 animal studies, 11 clinical studies, 3 healthy volunteer studies
- Searched PubMed, EMBASE and Cochrane CENTRAL
- 7 animal studies, 11 clinical studies, 3 healthy volunteer studies
Main finding
As reported in the abstract
- Slower infusion: lower mortality (studies)
- 2
- Slower infusion: lower blood loss (studies)
- 1
- Slower infusion: better or more sustained plasma volume expansion and less edema (studies)
- 3
- Slower infusion: slower restoration of BP (studies)
- 1
- Healthy volunteer studies suggesting more effective plasma expansion with slower infusion
- 3
- Postoperative trial with no plasma volume differences between infusion rates
- 1
Original publication
Physiological and linical ffects of ifferent nfusion ates of ntravenous luids for olume xpansion: A coping eview. J Crit Care. Published 29 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →