Plasma citrulline concentration and plasma LPS detection among critically ill patients a prospective observational study
Authors' conclusion
Plasma citrulline is not associated with the level of plasma LPS but is strongly decreased among septic patients.
Study context
- Population
- Critically ill patients admitted to the ICUSOFA score 8 [6–12]
- Participants
- 109 patients
- Exposure
- Sepsis vs no sepsis at ICU admission
- Sepsisn = 66
- Outcome
- Correlation of plasma citrulline (marker of enterocyte mass) with plasma LPS (potential marker of bacterial translocation)
- Follow-up
- ICU admission
Main finding
As reported in the abstract
Correlation of plasma citrulline with plasma LPS concentration or activity
- No correlation between plasma citrulline concentration and plasma LPS concentration or activity
Observational data: associations, not effects.
Further findings
Plasma citrulline concentration · ICU admission
P = 0.02
| Outcome | P value |
|---|---|
| Plasma LPS activity, abdominal vs extra-abdominal sepsis (subgroup) · ICU admission | P = 0.01 |
- Plasma LPS activity, abdominal vs extra-abdominal sepsis (subgroup): Abdominal sepsis 1.04 EU/mL
- Plasma LPS activity, abdominal vs extra-abdominal sepsis (subgroup): Extra-abdominal sepsis 0.63 EU/mL
Original publication
Plasma citrulline concentration and plasma LPS detection among critically ill patients a prospective observational study. J Crit Care. Published 3 October 2023. doi:10.
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