Plasma endostatin and its association with new-onset acute kidney injury in critical care
Authors' conclusion
Endostatin at ICU admission is an independent predictor of new-onset AKI and may improve early AKI risk assessment in the ICU. However, its predictive value for RRT and 30-day mortality appears limited.
Study context
- Population
- Intensive care unit (ICU) admissions to four ICUs
- Participants
- 4,732 admissions
- Exposure
- Plasma endostatin at ICU admission vs creatinine and cystatin C as predictors
- Outcome
- New-onset AKI (KDIGO criteria)
- Follow-up
- Within 48 h after ICU admission
Methodological details4 ICUs, prospectively obtained samples, retrospectively analysed, repeated cross-validation
- 4 ICUs
- Prospectively obtained samples, retrospectively analysed
- Repeated cross-validation
Main finding
As reported in the abstract
New-onset AKI
Odds ratio (95% CI)
Endostatinindependent of creatinine, cystatin C, and SAPS-3
1.7(1.5–1.9)
- Endostatin vs Creatinine and cystatin C · endostatin superior
- mean AUC 0.67 vs. 0.63; P < 0.001
Observational data: associations, not effects.
Further findings
New-onset stage 3 acute kidney injury (AKI)
| OR (95% CI) | ||
|---|---|---|
| EndostatinIndependent of creatinine, cystatin C, and SAPS-3 | 1.4 (1.2–1.6) | |
| 0.512Odds ratio (log scale) |
Renal replacement therapy (RRT) · within 7 days after ICU admission
| OR (95% CI) | ||
|---|---|---|
| EndostatinIndependent of creatinine, cystatin C, and SAPS-3 | 1.2 (1.05–1.4) | |
| 0.512Odds ratio (log scale) |
New-onset stage 3 AKI
- Adding endostatin to creatinine improved prediction of new-onset stage 3 AKI
RRT · within 7 days after ICU admission
- Adding endostatin to creatinine did not improve prediction of need for RRT
30-day mortality
- Endostatin not associated with 30-day mortality after adjusting for SAPS-3
Original publication
Plasma endostatin and its association with new-onset acute kidney injury in critical care. J Intensive Care. Published 2 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →