Cardiothoracic & vascular anesthesia
Plasma fibrinogen level and severe bleeding in cardiac surgery: an observational post hoc study of the Albumin in Cardiac Surgery (ALBICS) trial
Authors' conclusion
The preoperative fibrinogen level had borderline and the post-CPB fibrinogen level had strong associations with severe bleeding and resternotomy in patients undergoing on-pump cardiac surgery.
Study context
- Population
- Patients undergoing on-pump cardiac surgery enrolled in the Albumin in Cardiac Surgery (ALBICS) trial
- Participants
- 1,386 patients
- Comparison
- Plasma fibrinogen level vs severe bleeding and resternotomy
- Primary endpoint
- Severe bleeding (UDPB-high, classes 3-4) and resternotomy for bleeding
Methodological detailsobservational, post hoc
- Observational
- Post hoc
Primary result
As reported in the abstract
UDPB-high and resternotomy by fibrinogen level
- Incidence of UDPB-high
- 8.1% (112/1,386)
- Incidence of resternotomy
- 3.6% (50/1,386)
- Preoperative fibrinogen predicted UDPB-high, OR per SD (0.9 g·L-1), adjusted
- 0.77 (95% CI 0.60 to 0.98)
- Preoperative fibrinogen predicted resternotomy, OR per SD (0.9 g·L-1), adjusted
- 0.65 (95% CI 0.43 to 0.98)
- Post-CPB fibrinogen predicted UDPB-high, OR per preoperative SD (0.9 g·L-1)
- 0.51 (95% CI 0.33 to 0.77)
- Post-CPB fibrinogen predicted resternotomy, OR per preoperative SD (0.9 g·L-1)
- 0.31 (95% CI 0.16 to 0.62)
Original publication
Plasma fibrinogen level and severe bleeding in cardiac surgery: an observational post hoc study of the ALBICS trial. Can J Anaesth. Published 30 October 2025. doi:10.
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