Pediatric anesthesia & critical care
Plasma Lidocaine Concentrations During Intravenous Lidocaine Infusion Therapy in the Pediatric Population—A Scoping Review
Authors' conclusion
Reported plasma concentrations were detectable and lower than presumed toxic levels with one reported adverse event.
Study context
- Population
- Healthy 1–18-year-olds receiving IV lidocaine infusion therapy
- Participants
- 174 participants · 4 studies
- Comparison
- 1.5 mg/kg bolus + 1 mg/kg/h vs 1.5 mg/kg bolus + 2 mg/kg/h vs 1.5 mg/kg bolus + 1.5 mg/kg/h
- 1.5 mg/kg bolus + 1 mg/kg/hn = 22
- 1.5 mg/kg bolus + 2 mg/kg/hn = 46
- 1.5 mg/kg bolus + 1.5 mg/kg/hn = 106
- Outcome
- Plasma lidocaine and/or metabolite levels
Methodological detailsnarrative data synthesis
- Narrative data synthesis
Main finding
As reported in the abstract
Plasma lidocaine concentrations
1.5 mg/kg bolus + 1 mg/kg/h
2.82
mean · SD 0.65 · μg/mL
1.5 mg/kg bolus + 2 mg/kg/h
4 to < 5
peak · μg/mL
1.5 mg/kg bolus + 1.5 mg/kg/h
< 5
μg/mL
Safety
- Only adverse event: transient sensory disturbances in a single participant
- 1
Original publication
Plasma Lidocaine Concentrations During Intravenous Lidocaine Infusion Therapy in the Pediatric Population—A Scoping Review. Paediatr Anaesth. Published 4 June 2026. doi:10.
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