Hemodynamics, fluids & transfusion
Platelet dysfunction in heatstroke-induced coagulopathy: A retrospective observational study
Authors' conclusion
These results suggested that platelet dysfunction occurs in heatstroke-induced DIC, indicating that platelet function evaluation by TEG can provide complementary information and enhance our understanding about the subtypes of heatstroke.
Study context
- Population
- Intensive care unit (ICU)-admitted patients with heatstroke
- Participants
- 31 patients
- Outcome
- Association of platelet function by thromboelastography (TEG) (CFF-MA minus CRT-MA) at the emergency department (ED) with DIC severity (JAAM score; DIC ≥ 4 points)
Methodological detailssingle-centre, tertiary hospital
- Single-centre
- Tertiary hospital
Main finding
As reported in the abstract
Platelet count, median (IQR 12.6-25.0 × 104/μL)
18.1 × 104/μL
Platelet function citrated functional fibrinogen-maximum amplitude (CFF-MA)−citrated rapid TEG-maximum amplitude (CRT-MA), median (IQR 27.8-37.8 mm)
34.4 mm
Correlation of platelet function with disseminated intravascular coagulation (DIC) score (p < 0.001)
R = −0.63
AUC of platelet function for DIC development
0.87
95% CI 0.72–0.99
Observational data: associations, not effects.
Original publication
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