Cardiothoracic & vascular anesthesia
Supplemental fibrinogen restores thrombus formation in cardiopulmonary bypass-induced platelet dysfunction ex vivo
Authors' conclusion
Single valve surgery using moderately hypothermic CPB induces partial platelet dysfunction. Thrombus formation was restored in an experimental study design by ex vivo supplementation of fibrinogen.
Study context
- Population
- Patients undergoing first-time elective isolated aortic valve surgery with moderately hypothermic CPB
- Participants
- 18 patients
- Comparison
- Post-CPB vs pre-CPB platelet function; supplemental fibrinogen ex vivo
- Outcome
- Platelet function and thrombus formation
Methodological detailsex vivo, repeated sampling
- Ex vivo
- Repeated sampling
Main finding
As reported in the abstract
- Unstimulated P-selectin positive cells, pre vs post CPB (P<0.01)
- 1.2% vs 7%
- Unstimulated annexin V mean fluorescence intensity, pre vs post CPB (P<0.05)
- 15.5 vs 17.2
- Stimulated P-selectin positive cells, pre vs post CPB (P<0.01)
- 52% vs 26%
- Stimulated annexin V mean fluorescence intensity, pre vs post CPB (P<0.05)
- 508 vs 325
- Thrombus area, pre vs post CPB (a.u.; P<0.05)
- 6820 vs 5230
- Thrombus formation with supplemental fibrinogen, pre CPB vs post CPB (a.u.; P<0.001); post-CPB thrombus area restored to levels comparable with or higher than pre-CPB baseline
- 20 324 vs 11 367
Original publication
Supplemental fibrinogen restores thrombus formation in cardiopulmonary bypass-induced platelet dysfunction ex vivo. Br J Anaesth. Published 20 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →