Sepsis-induced coagulopathy and outcomes – What about bleeding? A propensity score-matched study in critically ill patients with septic shock
Authors' conclusion
SIC was prevalent in 31% of patients at ICU admission and was associated with higher ICU-mortality, fewer days alive and free of vasopressors, more critical bleeding events and more red blood cell transfusions.
Study context
- Population
- Critically ill patients admitted with septic shock, 2011 to March 2024422 (31%) had sepsis-induced coagulopathy (SIC)
- Participants
- 1,367 patients
- Exposure
- SIC vs control at intensive care unit (ICU) admission
- SICn = 340
- Controln = 340reference
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Main finding
As reported in the abstract
P = 0.091
Observational data: associations, not effects.
Further findings
ICU mortality
P = 0.016
RBC transfusion
P = 0.009
Days alive and free of vasopressors
P = 0.046
Other outcomes (90-, 180-day mortality, days alive and free of mechanical ventilation and renal replacement therapy (RRT), use of RRT)
- No significant difference
Safety
Critical bleeding events
P = 0.009
Original publication
Sepsis-induced coagulopathy and outcomes – What about bleeding? A propensity score-matched study in critically ill patients with septic shock. J Crit Care. Published 27 March 2026. doi:10.
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