The interplay between microcirculatory dysfunction and coagulopathy in patients with sepsis: An exploratory single-center observational study
Authors' conclusion
The sublingual microcirculation on day 0 failed to predict the development of SIC. In longitudinal exploratory analysis, SIC was associated with a reduction in microvascular density from day 0 to day 4, although a causal relationship remains to be established.
Study context
- Population
- Septic patients
- Participants
- 30 patients
- Exposure
- Sepsis-induced coagulopathy (SIC)+ vs SIC- patients
- SIC+n = 20
- Outcome
- Whether early microvascular impairment (sublingual microcirculation, incident dark-field video-microscopy) predicts presence/development of SIC
- Follow-up
- Day 4
Methodological detailssingle-centre, exploratory
- Single-centre
- Exploratory
Main finding
As reported in the abstract
Development of SIC by baseline MFI
P = 0.037
- SIC identified by day 4
- 20 patients (66.7%)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | P value |
|---|---|
| Change in microvascular density (TVD, PVD), day 0 to day 4Interaction P | P for interaction < 0.05 |
Change in microvascular density (TVD, PVD), day 0 to day 4
- Decreased in SIC+, increased in SIC-
Baseline syndecan-1 vs Δ microvascular density
- Negative correlation
Δ-microcirculatory vs Δ-coagulation markers
- Δ-MFI and Δ-INR
- r = −0.516, p < 0.05
- Δ-TVD and Δ-platelets
- r = 0.442, p < 0.05
Original publication
The interplay between microcirculatory dysfunction and coagulopathy in patients with sepsis: An exploratory single-center observational study. J Crit Care. Published 19 June 2026. doi:10.
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