Hemodynamics, fluids & transfusion
Platelet transfusions in adult intensive care unit (ICU) patients with thrombocytopenia: A sub‐study of the PLOT‐ICU inception cohort study
Authors' conclusion
Among acutely admitted, adult ICU patients with thrombocytopenia, 20.8% received platelet transfusions in ICU of whom most received pooled products, but considerable variation was observed in product type, volumes and doses across countries. Prophylactic platelet transfusions were associated with limited increases in platelet counts.
Study context
- Population
- Acutely admitted adult ICU patients with thrombocytopenia (platelet count <150 × 109/L)
- Participants
- 504 participants · 43 hospitals · 10 countries
- Primary endpoint
- Number of patients receiving platelet transfusion in ICU by product type
Methodological detailsmulticentre, sub-study
- Multicentre
- Sub-study
Primary result
As reported in the abstract
Platelet transfusion in ICU and product type
- Received platelet transfusions
- 20.8%
- Platelet transfusions given
- 565
- Received pooled products
- 61.0%
- Received apheresis products
- 21.9%
- Received both
- 17.1%
- Median days from admission to first transfusion (IQR 1-4)
- 2
Secondary outcomes
Transfusion volume and product share
- Median volume per transfusion, mL (180-308 mL)
- 253
- Pooled products share of transfusions (varied across countries)
- 59.1%
Dosing strategy
- Centres using fixed dosing (medians 2.0 to 3.5 × 1011 platelets/transfusion)
- 73.8%
- Weight-based dosing (mainly France), × 1011 platelets per 10 kg body weight
- 0.5 to 0.7
Platelet count increment after single prophylactic platelet transfusion
- Median increment, × 109/L (−1 to 8)
- 2
Outcomes of transfused vs non-transfused patients
- Outcomes of patients who did and did not receive platelet transfusions varied
Original publication
Platelet transfusions in adult ICU patients with thrombocytopenia: A sub‐study of the PLOT‐ICU inception cohort study. Acta Anaesthesiol Scand. Published 5 June 2024. doi:10.
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