Hemodynamics, fluids & transfusion
Thrombocytopenia and platelet transfusions in intensive care unit (ICU) patients: an international inception cohort study (PLOT-ICU)
An erratum to this article was published (Intensive Care Med, Jan 2024 ↗)
Authors' conclusion
Thrombocytopenia occurred in 43% of critically ill patients and was associated with worse outcomes including increased mortality.
Study context
- Population
- Adult ICU patients in 52 ICUs across 10 countries
- Participants
- 1,166 patients · 52 ICUs · 10 countries
- Exposure
- Thrombocytopenia vs no thrombocytopenia
- Outcome
- Frequency of thrombocytopenia
Methodological detailsinternational, multicentre, pre-specified logistic regression analyses
- International
- Multicentre
- Pre-specified logistic regression analyses
Main finding
As reported in the abstract
Thrombocytopenia overall
43.2%
95% CI 40.4–46.1
Thrombocytopenia at ICU admission
23.4%
95% CI 20–26
Thrombocytopenia developed during ICU stay
19.8%
95% CI 17.6–22.2
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Mortality by thrombocytopenia at ICU admission · 90 daysThrombocytopenia at ICU admission | 1.7 (1.19–2.42) | |
| 0.512Adjusted odds ratio (log scale) |
Platelet transfusions among patients with thrombocytopenia
- Received platelet transfusion(s)
- 22.6%
- In-ICU transfusions that were prophylactic
- 64.3%
Risk factors for thrombocytopenia during ICU stay
- Absence of AIDS, non-cancer-related immune deficiency, liver failure, male sex, septic shock and bleeding at ICU admission associated with development of thrombocytopenia
Bleeding, death, days alive without life-support, days alive and out of hospital
- Thrombocytopenia: more bleeding and death, fewer days alive without life-support and fewer days alive and out of hospital
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →