Population pharmacokinetics and model-based dosing optimization of teicoplanin in elderly critically ill patients with pneumonia
Authors' conclusion
Standard teicoplanin dosages for pneumonia may provide inadequate systemic exposures in elderly critically ill patients.
Study context
- Population
- Critically ill patients ≥ 60 years with pneumonia receiving teicoplanin 6 mg/kg ×3 then 6 mg/kg q24h with renal dosing adjustment9 men
- Participants
- 15 patients
- Outcome
- Teicoplanin population PK (CL, V2 by CrCl) and probability of target attainment (PTA) of dosing regimens
Methodological detailsNONMEM population pharmacokinetic modeling, Monte Carlo simulations
- NONMEM population pharmacokinetic modeling
- Monte Carlo simulations
Main finding
As reported in the abstract
Median (IQR) peak concentration, mg/L
46.5
42.7–51.0
Median (IQR) trough concentration, mg/L
8.7
7.2–9.5
Original publication
Population pharmacokinetics and model-based dosing optimization of teicoplanin in elderly critically ill patients with pneumonia. J Crit Care. Published 25 August 2023. doi:10.
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