Population pharmacokinetics of fibrinogen in postpartum haemorrhage during Caesarean section: a secondary analysis of the TRACES trial
Authors' conclusion
This work supports that an individualized target-controlled fibrinogen dosing strategy is probably required to effectively correct fibrinogen levels. Integrating such models as a clinical decision support tool into a multimodal strategy that also utilizes viscoelastic testing could optimize PPH management.
Study context
- Population
- Women with PPH > 800 ml during caesarean sectionwomen with PPH > 800 ml during caesarean section, 31 received fibrinogen replacement, 593 plasma fibrinogen concentrations
- Participants
- 142 women
- Outcome
- Pharmacokinetic model of plasma fibrinogen
Methodological detailspopulation pharmacokinetic model, nonlinear mixed-effects modeling, simulations
- Population pharmacokinetic model
- Nonlinear mixed-effects modeling
- Simulations
Main finding
As reported in the abstract
- A one-compartment logistic model adequately described plasma fibrinogen levels
- Bleeding rate identified as a key covariate to explain fibrinogen loss rate
Further findings
Fibrinogen loading dose required for a target increase of 1 g.L-¹ in plasma fibrinogen level (body weight 50 kg)
- Required fibrinogen loading dose
- at least 2.7 g
- Simulation
Fibrinogen infusion rate to maintain plasma fibrinogen at a target of 2 g.L-¹ during a 1000 mL.h-¹ bleeding rate
- Required fibrinogen infusion rate
- 0.9 g.h-¹
- Simulation
Original publication
Population pharmacokinetics of fibrinogen in postpartum haemorrhage during Caesarean section: a secondary analysis of the TRACES trial. Anaesth Crit Care Pain Med. Published 6 November 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →