Population-specific genetic-risk scores enable improved prediction of mortality within 28 days of sepsis onset: a retrospective Taiwanese cohort study
Authors' conclusion
This study proposed genetic-risk models specific for Taiwanese populations that outperformed clinical-only models. Also it established a strong racial-effect on the underlying genetics of sepsis-related mortality.
Study context
- Population
- Taiwanese patients diagnosed with sepsis
- Participants
- 1,403 patients
- Exposure
- PRS-sepsis model vs Clinical-only vs European SNP model
- Outcome
- Death within 28 days from sepsis onset
- Follow-up
- 28 days
Methodological detailsgenome-wide survival analysis, polygenic risk score (clumping and thresholding)
- Genome-wide survival analysis
- Polygenic risk score (clumping and thresholding)
Main finding
As reported in the abstract
Prediction of 28-day mortality
| Group | C-index [CI] | AUROC [CI] |
|---|---|---|
| PRS-sepsis model | 0.79 [0.62-0.96] | 0.78 [0.75-0.80] |
| Clinical-only | 0.63 [0.45- 0.81] | 0.61 [0.58-0.64] |
| European SNP model | 0.63 [0.42-0.85] | 0.60 [0.58-0.63] |
C-index [CI]
PRS-sepsis model0.79 [0.62-0.96]
Clinical-only0.63 [0.45- 0.81]
European SNP model0.63 [0.42-0.85]
AUROC [CI]
PRS-sepsis model0.78 [0.75-0.80]
Clinical-only0.61 [0.58-0.64]
European SNP model0.60 [0.58-0.63]
Observational data: associations, not effects.
Further findings
Genome-wide significant single-nucleotide-polymorphisms (SNPs)
- SNPs reaching genome-wide significance (p < 5e-8)
- 5
- SNPs reaching suggestive significance (p < 1e-5)
- 86
Survival by PRS (Kaplan-Meier)
- Higher PRSs had inferior survival probability vs lower PRSs
Original publication
Population-specific genetic-risk scores enable improved prediction of mortality within 28 days of sepsis onset: a retrospective Taiwanese cohort study. J Intensive Care. Published 26 February 2025. doi:10.
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