Cardiothoracic & vascular anaesthesia

Postoperative delirium: An independent risk factor for poorer quality of life with long-term cognitive and functional decline after cardiac surgery

J Clin AnesthPublished Prospective observational study

Authors' conclusion

Postoperative delirium is a risk factor for decreased quality of life in patients 3 years after heart surgery, being associated with greater cognitive and functional deterioration, as well as greater risk of hospital readmission.

Study context

Population
Consecutive adults (≥18 years) undergoing cardiac surgery (DELIPRECAS study)
Participants
313 adults
Exposure
Postoperative delirium vs no delirium
Outcome
Cognitive and functional status (telephone interview) and influence of CAM-ICU-diagnosed postoperative delirium
Follow-up
3 years after cardiac surgery

Main finding

As reported in the abstract

Long-term cognitive and functional problems (delirium as independent risk factor) · 3 years
Delirium vs No deliriumOdds ratio (95% CI)P value
Memory problems
6.11(2.54–14.68)
P < 0.001
Concentration
11.20(3.58–35.09)
P > 0.001
Confusion/disorientation
10.93(3.61–33.12)
P > 0.001
Nightmares
8.99(1.98–40.90)
P = 0.004
Emotional problems
4.30(1.87–9.91)
P = 0.001
Poorer mobility after hospital discharge
2.436(1.06–5.61)
P = 0.037
Sleep problems
OR 5.21 (95% CI 2 0.29 to 11.84); P < 0.001

Observational data: associations, not effects.

Further findings

Hospital readmissions

P = 0.022

Original publication

Postoperative delirium: An independent risk factor for poorer quality of life with long-term cognitive and functional decline after cardiac surgery. J Clin Anesth. Published 1 December 2022. doi:10.1016/j.jclinane.2022.111030

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