Perioperative medicine & outcomes
Postoperative Delirium Severity and Recovery Correlate With Electroencephalogram Spectral Features
Authors' conclusion
Presence, severity, and core features of postoperative delirium covary with spectral features of the EEG.
Study context
- Population
- Adults undergoing major surgery requiring GA, enrolled in ENGAGES
- Participants
- 26 adults
- Primary endpoint
- Association of EEG oscillation frequencies (relative delta, theta, alpha power) with postoperative delirium onset, severity and recovery (confusion assessment method (CAM) or CAM-ICU)
Methodological detailslongitudinal postoperative EEG, mixed-effects models, Bonferroni-corrected confidence intervals (CIs)
- Longitudinal postoperative EEG
- Mixed-effects models
- Bonferroni-corrected CIs
Primary result
As reported in the abstract
EEG spectral features vs delirium presence and severity
- Occipital alpha relative power, eyes closed: discriminability for delirium
- 0.75 (c-statistic; 98% CI 0.58-0.87)
- Occipital alpha relative power, eyes closed, vs delirium severity
- −0.67 (slope; 98% CI −1.36 to −0.01; P = .01)
- Occipital alpha relative power, eyes closed, vs inattention severity
- −1.44 (slope; 98% CI −2.30 to −0.58; P = .002)
- Occipital theta relative power, eyes open, vs delirium severity
- 1.28 (slope; 98% CI 0.12-2.44; P = .007)
- Occipital theta relative power, eyes open, vs inattention
- 2.00 (slope; 98% CI 0.48-3.54; P = .01)
- Occipital theta relative power, eyes open, vs disorganized thinking
- 3.15 (slope; 98% CI 0.66-5.65; P = .01)
- Frontal theta relative power, eyes open, vs altered level of consciousness severity
- 11.52 (slope; 98% CI 6.33-16.71; P < .001)
Further findings
Frontal theta relative power, eyes open, over time (recovery)
- Change in relative power/day
- −0.05 (slope; 98% CI −0.12 to −0.04; P = .002)
Original publication
Postoperative Delirium Severity and Recovery Correlate With Electroencephalogram Spectral Features. Anesth Analg. Published 13 May 2022. doi:10.
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