Postoperative delirium under general anaesthesia by remimazolam versus propofol: A systematic review and meta-analysis of randomised controlled trials
Pooled resultResult — go to the resultOdds ratio 0.92 95% CI 0.58–1.44Authors' conclusion
Perioperative remimazolam administration did not increase POD and reduced the risk of intraoperative hypotension compared to propofol.
Study context
- Population
- Patients undergoing GA (randomised controlled trials (RCTs) comparing remimazolam with propofol and reporting postoperative delirium (POD))
- Participants
- 1,107 patients · 6 RCTs
- Comparison
- Remimazolam vs propofol for GA
- Outcome
- Incidence of POD
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
Odds ratio
0.92
95% CI 0.58–1.44
Remimazolam vs Propofol
OR 0.92 (95% CI 0.58–1.44)
Further pooled results
POD incidence, older patients ≥60 years (sensitivity analysis, 3 RCTs)
- No significant difference in the incidence of POD
- OR, 1.00; 95 % CI, 0.52-1.93
- Sensitivity analysis
Time to extubation, awakening time and other secondary outcomes
- No significant differences in other secondary outcomes
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| Intraoperative hypotension | 0.31 (0.21–0.46) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Postoperative delirium under general anaesthesia by remimazolam versus propofol: A systematic review and meta-analysis of randomised controlled trials. J Clin Anesth. Published 30 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →