Cardiothoracic & vascular anesthesia
Postoperative Transfusions after Administration of Delayed Cold-stored Platelets versus Room Temperature Platelets in Cardiac Surgery: A Retrospective Cohort Study
Main findingResult — go to the resultAdjusted odds ratio 1.65 95% CI 1.13–2.39Authors' conclusion
In adults undergoing cardiac surgery, delayed cold-stored platelets were associated with higher postoperative transfusion utilization and lower platelet counts compared to room temperature-stored platelets without differences in clinical outcomes.
Study context
- Population
- Adults transfused with platelets intraoperatively during elective cardiac surgery, April 2020–May 2021
- Participants
- 713 patient encounters
- Exposure
- Delayed cold-stored platelets vs Room temperature-stored platelets
- Delayed cold-stored plateletsn = 184
- Room temperature-stored plateletsn = 529reference
- Outcome
- Allogenic transfusion exposure
- Follow-up
- First 24 h postoperatively
Methodological detailsobservational, Platelet storage type assigned by blood bank availability, not clinical features or provider preference
- Observational
- Platelet storage type assigned by blood bank availability, not clinical features or provider preference
Main finding
As reported in the abstract
Adjusted odds ratio
1.65
95% CI 1.13–2.39
P = 0.009
Events by group
Delayed cold-stored platelets vs Room temperature-stored platelets
aOR 1.65 (95% CI 1.13–2.39); P = 0.009
Observational data: associations, not effects.
Further findings
| Outcome | Room temperature-stored platelets | Delayed cold-stored platelets | aOR (95% CI) | P value | |
|---|---|---|---|---|---|
| Erythrocyte transfusion · first 24 h postoperatively | 26% | 35% | 1.54 (1.03–2.29) | P = 0.035 | |
| Platelet transfusion · first 24 h postoperatively | 15% | 26% | 1.91 (1.22–2.99) | P = 0.005 | |
| 0.20.5125Adjusted odds ratio (log scale) |
| Outcome | Difference (× 109/l) (95% CI) | |
|---|---|---|
| Platelet count · through first 3 days postoperativelyModestly lower | −9 (−16 to −3) | |
| −20−10010Difference, × 109/l (linear scale) |
Units administered postoperatively among those transfused
- No difference
Safety
Reoperation for bleeding, postoperative chest tube output, clinical outcomes
- No significant differences
Original publication
Postoperative Transfusions after Administration of Delayed Cold-stored Platelets versus Room Temperature Platelets in Cardiac Surgery: A Retrospective Cohort Study. Anesthesiology. Published 8 May 2023. doi:10.
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