Cardiothoracic & vascular anesthesia
Cold-stored platelets for acute bleeding in cardiac surgical patients: a narrative review
Authors' conclusion
Cold-stored platelets may have several advantages over RTP, including increased hemostatic capacity, extended shelf-life, and reduced risk of bacterial contamination.
Study context
- Population
- Adult cardiac surgical patients with acute bleeding
- Exposure
- Cold-stored platelets vs room-temperature platelets
Methodological detailstargeted literature search, trial registry search, Targeted search of MEDLINE and other databases up to 24 February 2022, plus ClinicalTrials.gov and WHO ICTRP
- Targeted literature search
- Trial registry search
- Targeted search of MEDLINE and other databases up to 24 February 2022, plus ClinicalTrials.gov and WHO ICTRP
Main finding
As reported in the abstract
- Storage at 1-6 °C slows platelet metabolic rate, preserving hemostatic function for increased storage duration
- Cold-stored platelets (CSP) have superior adhesion under physiologic shear conditions and similar or superior aggregation responses to physiologic agonists
- CSP undergo structural, metabolic and molecular changes that appear to "prime" them for hemostatic activity
- Preliminary clinical evidence supports trials comparing CSP with room-temperature platelets (RTP) in platelet-related bleeding, e.g. cardiac surgery
Observational data: associations, not effects.
Original publication
Cold-stored platelets for acute bleeding in cardiac surgical patients: a narrative review. Can J Anaesth. Published 13 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →