Cardiothoracic & vascular anesthesia
Postoperative vasoplegia in lung transplantation: incidence and relation to outcome in a single-centre retrospective study
Authors' conclusion
Influenced by preoperative status as well as procedural factors and inflammatory response, vasoplegia is a common and critical condition after lung transplantation with worse short-term outcomes and long-term survival.
Study context
- Population
- Lung transplant recipients operated on 2015–2020 in a UK hospital
- Participants
- 279 recipients
- Exposure
- Vasoplegia vs no vasoplegia after lung transplantation
- Outcome
- Incidence of vasoplegia after lung transplantation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Vasoplegia
41.6%
Mild (of vasoplegia)
31.0%
Moderate (of vasoplegia)
55.2%
Severe (of vasoplegia)
13.8%
Observational data: associations, not effects.
Further findings
Any AKI (KDIGO criteria)
P = 0.015
RRT
P < 0.001
Delayed chest closure
P = 0.025
Duration of ventilation · spread printed in brackets, kind not named
P < 0.001
ICU LOS · spread printed in brackets, kind not named
P < 0.001
| Outcome | HR | P value |
|---|---|---|
| Longer-term mortality, severe vasoplegia as predictor | 1.65 | P = 0.008 |
Mortality · 30 days and 1 yr
- Mortality at 30 days, with vs without vasoplegia
- 11.2% vs 5.5%
- Mortality at 1 yr, with vs without vasoplegia
- 20.7% vs 11.7%
- Higher in patients with vasoplegia
- P=0.039, respectively
Predictors of vasoplegia severity
- Underlying infectious disease, increased BMI, higher preoperative pulmonary artery systolic pressure and bilirubin, lower GFR, and increased FFP transfusion predicted vasoplegia severity
Inflammatory markers
- Neutrophilia, leucocytosis and increased C-reactive protein associated with vasoplegia
- Release of myeloperoxidase and heparin-binding protein similar between groups
Original publication
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