Predicting a strongly positive fluid balance in critically ill patients with acute kidney injury: A multicentre, international study
Authors' conclusion
We developed and validated the "AKI-FB risk score" to predict patients who developed a positive FB >2 L within 72 h of AKI diagnosis.
Study context
- Population
- Critically ill patients with acute kidney injury (AKI)
- Outcome
- Positive fluid balance >2 L after AKI diagnosis
- Follow-up
- 72 h
Methodological detailsmulticentre, international, external validation
- Multicentre
- International
- External validation
Performance
As reported in the abstract
Prediction of a >2 L positive FB at 72 h after AKI diagnosis
| Test or model | Threshold | Sensitivity | Specificity | AUC-ROC |
|---|---|---|---|---|
| AKI-FB risk score | 32 | 75 % | 72 % | 0.805; 95 % CI 0.799 to 0.810 |
AKI-FB risk score
Threshold32
Sensitivity75 %
Specificity72 %
AUC-ROC0.805; 95 % CI 0.799 to 0.810
- External validation AUC (British cohort)
- 0.761 (95 % CI 0.746 to 0.775)
Further findings
Key score variables
- Admission after trauma, sepsis or septic shock; on day of AKI diagnosis: highest creatinine, daily cumulative fluid balance (FB), mechanical ventilation, noradrenaline use, noradrenaline equivalent dose >0.07 μg/kg/min, lactate ≥2 mmol/L, transfusion, nutritional support
Original publication
Predicting a strongly positive fluid balance in critically ill patients with acute kidney injury: A multicentre, international study. J Crit Care. Published 23 January 2025. doi:10.
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