Cardiothoracic & vascular anesthesia
Preemptive Pharmacogenetic-Guided Metoprolol Management for Postoperative Atrial Fibrillation in Cardiac Surgery: The Preemptive Pharmacogenetic-Guided Metoprolol Management for Atrial Fibrillation in Cardiac Surgery Pilot Trial
Authors' conclusion
A CYP2D6 genotype-guided metoprolol management was not associated with a reduction of postoperative AF after cardiac surgery.
Study context
- Population
- Cardiac surgery patients, single academic center
- Participants
- 73 patients
- Comparison
- Normal metabolizers vs Poor/intermediate metabolizers
- Normal metabolizersn = 65reference
- Poor/intermediate metabolizersn = 8
- Outcome
- Postoperative AF in altered metabolizers vs historical reference
Methodological detailssingle-centre, historical reference comparison, Bayesian analysis
- Single-centre
- Historical reference comparison
- Bayesian analysis
Main finding
As reported in the abstract
Further findings
Postoperative atrial fibrillation (AF), whole cohort
- Postoperative AF among the 73 patients (n = 22)
- 30%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Preemptive Pharmacogenetic-Guided Metoprolol Management for Postoperative Atrial Fibrillation in Cardiac Surgery: The Preemptive Pharmacogenetic-Guided Metoprolol Management for Atrial Fibrillation in Cardiac Surgery Pilot Trial. J Cardiothorac Vasc Anesth. Published 14 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →