Cardiothoracic & vascular anesthesia
Use of a New Standardized Unfractionated Heparin Protocol for Left-Sided Ablation Procedures Improves Time in the Therapeutic Activated Clotting Time (ACT) Range
Authors' conclusion
During catheter-based cardiac ablation procedures, a novel standardized unfractionated heparin dosing protocol resulted in a higher percentage of ACTs in the target range, and a higher proportion of initial ACTs in the therapeutic range compared with baseline nonstandardized heparin dosing.
Study context
- Population
- Patients undergoing catheter-based atrial fibrillation ablation at a tertiary-care teaching hospital, New Orleans, LA
- Participants
- 202 vs 173
- Exposure
- Intervention vs Control
- Interventionn = 202
- Controln = 173reference
- Outcome
- Percentage of intraprocedural ACTs in therapeutic range (≥300 to <450 s)
Methodological detailshistoric controls, single-centre
- Historic controls
- Single-centre
Main finding
As reported in the abstract
Mean percentage of ACTs in therapeutic range
P < 0.001
Observational data: associations, not effects.
Secondary outcomes
Therapeutic ACT (≥300 s) on first measurement
P < 0.001
Original publication
Use of a New Standardized Unfractionated Heparin Protocol for Left-Sided Ablation Procedures Improves Time in the Therapeutic ACT Range. J Cardiothorac Vasc Anesth. Published 7 November 2023. doi:10.
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