Hemodynamics, fluids & transfusion
Preliminary insights into monitoring bivalirudin anticoagulation: A retrospective cohort study of activated partial thromboplastin time (aPTT) versus a chromogenic anti-IIa assay
Authors' conclusion
These findings suggest that the anti-IIa assay provides more reliable bivalirudin monitoring than aPTT, with a significant reduction in minor bleeding.
Study context
- Population
- Adults receiving bivalirudin anticoagulation127 samples
- Participants
- 11 adults
- Exposure
- Anti-IIa assay vs aPTT
- Outcome
- Correlation between bivalirudin dose and aPTT or anti-IIa assay
Methodological detailsretrospective comparative cohort
- Retrospective comparative cohort
Main finding
As reported in the abstract
Correlation of bivalirudin dose with assay
Dose-response slope CV
| Outcome | Anti-IIa assay | aPTT |
|---|---|---|
| r2 | 0.65 | 0.08 |
Observational data: associations, not effects.
Further findings
Time in therapeutic range
P < 0.001
Original publication
Preliminary insights into monitoring bivalirudin anticoagulation: A retrospective cohort study of aPTT versus a chromogenic anti-IIa assay. J Clin Anesth. Published 16 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →