Preoperative oral caffeine as prophylaxis against post-spinal hypotension in patients undergoing orthopedic lower limb surgery: A randomized, placebo-controlled, double-blinded study
Authors' conclusion
The preoperative ingestion of a 200 mg caffeine tablet could decrease the number of patients with hypotensive episodes and ephedrine requirements within the first hour of spinal anesthesia.
Study context
- Population
- Patients aged 18–70 years undergoing lower limb orthopedic surgery under spinal anesthesia1 lost to follow-up
- Participants
- 80 patients
- Comparison
- Preoperative oral caffeine 200 mg tablet vs placebo
- Caffeinen = 40
- Controln = 40reference
- Primary endpoint
- Patients with ≥1 hypotensive episode (mean arterial pressure (MAP) <60 mmHg or >20% decrease in MAP from baseline)
- Follow-up
- Within the first hour of spinal anesthesia
Methodological detailsplacebo-controlled, double-blinded
- Placebo-controlled
- Double-blinded
Primary result
As reported in the abstract
P = 0.013
Secondary outcomes
Patients receiving ephedrine and ephedrine amount per patient · within the first hour of spinal anesthesia
- Significantly lower in the caffeine group than in the control group
Original publication
Preoperative oral caffeine as prophylaxis against post-spinal hypotension in patients undergoing orthopedic lower limb surgery: A randomized, placebo-controlled, double-blinded study. Anaesth Crit Care Pain Med. Published 1 May 2025. doi:10.
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