Respiratory failure & ventilation
Presence of procoagulant peripheral blood mononuclear cells in severe COVID-19 patients relate to ventilation perfusion mismatch and precede pulmonary embolism
Authors' conclusion
We show that the procoagulant state of PBMC could aid in early detection of PE in COVID-19 ICU patients.
Study context
- Population
- Severe COVID-19 ICU patients
- Participants
- 20 vs 15
- Comparison
- Pulmonary emboli (PE) vs Controls
- PEn = 20
- Controlsn = 15reference
- Outcome
- Procoagulant properties of peripheral blood mononuclear cells (PBMC) (modified fibrin generation time, MC-FGT) related to occurrence of PE
Methodological detailsICU biobank, functional bioassay
- ICU biobank
- Functional bioassay
Main finding
As reported in the abstract
MC-FGT
- MC-FGT levels highest in samples taken closest to PE detection, similar to the ETCO2 - PaCO2 gradient
Observational data: associations, not effects.
Further findings
MC-FGT and ETCO2 - PaCO2 gradient (patients without proven PE)
- Peak MC-FGT relates to an increase in ETCO2 - PaCO2 gradient
Tissue factor (TF) expression on monocyte subsets
- Non-classical, CD16 positive monocytes identified as the subset with increased TF expression
Original publication
Presence of procoagulant peripheral blood mononuclear cells in severe COVID-19 patients relate to ventilation perfusion mismatch and precede pulmonary embolism. J Crit Care. Published 16 November 2023. doi:10.
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