Hemodynamics, fluids & transfusion
Pressure response to fluid challenge administration in hypotensive surgical patients: a post-hoc pharmacodynamic analysis of five datasets
Authors' conclusion
In hypotensive patients, FC restores a MAP [Formula: see text] 65 mmHg after 5 min from infusion start. The hemodynamic profile of FC in hypotensive and normotensive patients is different; both the magnitude of pressure augmentation and duration is greater in the hypotensive group.
Study context
- Population
- Elective surgical patients receiving a fluid challenge (FC)102 (47.0%) fluid responders
- Participants
- Two hundred-seventeen patients
- Comparison
- Hypotensive vs normotensive response to fluid challenge
- Primary endpoint
- Effect of FC on arterial pressures (systolic, diastolic, mean, dicrotic), dynamic indexes of fluid responsiveness and arterial elastance (net AUC, dmax, tmax, d5)
- Follow-up
- 10-min infusion; 5 min after FC end
Primary result
As reported in the abstract
- On average, FC restored a mean arterial pressure (MAP) [Formula: see text] 65 mmHg after 5 min
- AUCs and dmax of pressure variables and arterial elastance significantly greater in hypotensive than normotensive patients
- Pressure variables and arterial elastance changes significantly higher at d5 in hypotensive vs normotensive group
Original publication
Pressure response to fluid challenge administration in hypotensive surgical patients: a post-hoc pharmacodynamic analysis of five datasets. J Clin Monit Comput. Published 5 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →