Prevalent diabetes and long-term cardiovascular outcomes in adult sepsis survivors: a population-based cohort study
Main finding · Major CVD (MI, stroke, cardiovascular death)Result — go to the resultHazard ratio 1.25 95% CI 1.22–1.29Authors' conclusion
Sepsis survivors with pre-existing diabetes experience a higher long-term hazard of major cardiovascular events when compared to sepsis survivors without diabetes.
Study context
- Population
- Adult survivors of a first sepsis-associated hospitalization without pre-existing CVD, Ontario, Canada, 2008–2017matched cohort
- Exposure
- Pre-existing diabetes vs no pre-existing diabetes among sepsis survivors
- Diabetesn = 78,638
- Outcome
- Composite of:
- MI
- Stroke
- Cardiovascular death
- Follow-up
- Up to 5 years from discharge
Methodological detailspropensity-score matched (1:1)
- Propensity-score matched (1:1)
Main finding
Major CVD (MI, stroke, cardiovascular death)
Hazard ratio
1.25
95% CI 1.22–1.29
Diabetes vs No diabetes
HR 1.25 (95% CI 1.22–1.29)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| MI | 1.40 (1.34–1.47) | |
| Stroke | 1.24 (1.18–1.29) | |
| 0.512Hazard ratio (log scale) |
| Outcome | Risk difference (%) (95% CI) | |
|---|---|---|
| Effect modification: CVD risk after sepsis vs no sepsis, by diabetes statusSepsis (with diabetes) vs No sepsis (with diabetes) | 2.3 (2.0–2.6) | |
| Effect modification: CVD risk after sepsis vs no sepsis, by diabetes statusSepsis (without diabetes) vs No sepsis (without diabetes) | 1.8 (1.6–2.0) | |
| −2024Difference, % (linear scale) |
Effect modification: CVD risk after sepsis vs no sepsis, by diabetes status
- Pre-existing diabetes modified the association between sepsis and CVD
Original publication
Prevalent diabetes and long-term cardiovascular outcomes in adult sepsis survivors: a population-based cohort study. Crit Care. Published 31 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →