Risk Factors for Major Cardiovascular Events in Adult Sepsis Survivors: A Population-Based Cohort Study*
Authors' conclusion
Classic cardiovascular risk factors, comorbid conditions, and characteristics of the sepsis episode were associated with a higher hazard of major cardiovascular events in adult sepsis survivors.
Study context
- Population
- Adults (≥18 yr) surviving a first sepsis hospitalization without preexisting CVD, Ontario, Canada (2008–2017)median age 72 yr
- Participants
- 268,259 adults
- Outcome
- Composite of:
- MI
- Stroke
- Cardiovascular death
- Follow-up
- Up to 5 years following hospital discharge
Methodological detailscause-specific Cox proportional hazards models accounting for competing risk of noncardiovascular death
- Cause-specific Cox proportional hazards models accounting for competing risk of noncardiovascular death
Main finding
As reported in the abstract
Factors associated with major cardiovascular events (multivariable-adjusted) · median follow-up 3 years
- Major cardiovascular event incidence
- 10.4%
- Age, HR per 10 yr
- 1.53 (95% CI 1.51-1.54)
- Male sex, HR
- 1.23 (95% CI 1.20-1.26)
- DM, HR
- 1.24 (95% CI 1.21-1.27)
- Hypertension, HR
- 1.34 (95% CI 1.30-1.38)
- Prevalent AF, HR
- 1.46 (95% CI 1.40-1.52)
- CKD, HR
- 1.11 (95% CI 1.06-1.16)
- Pneumonia vs other site of infection, HR
- 1.09 (95% CI 1.05-1.12)
- Septic shock, HR
- 1.08 (95% CI 1.05-1.11)
- RRT, HR
- 1.51 (95% CI 1.38-1.64)
Observational data: associations, not effects.
Further findings
Elevated troponin (patients with troponin measured during hospitalization)
- Elevated troponin, HR
- 1.23 (95% CI 1.13-1.33)
- 26,400 patients
Original publication
Risk Factors for Major Cardiovascular Events in Adult Sepsis Survivors: A Population-Based Cohort Study*. Crit Care Med. Published 15 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →