Prevention of hypotension after neuraxial anesthesia in nonobstetric surgery: a systematic review
Authors' conclusion
Several interventions hold promise for mitigating exposure to hypotension following neuraxial anesthesia, albeit supported by very-low to moderate-certainty evidence.
Study context
- Population
- Patients receiving neuraxial anesthesia for major nonobstetric noncardiac surgery
- Participants
- 3,880 patients · 33 randomized controlled trials (RCTs)
- Comparison
- Interventions to prevent hypotension after neuraxial anaesthesia vs any comparator
- Outcome
- Hypotension
Pooled result
As reported in the abstract
Relative risk (95% CI)P value
Colloid preload vs CrystalloidI2 = 12%; very-low-certainty evidence
0.48(0.30–0.80)
P = 0.004Ondansetron vs PlaceboI2 = 39%; moderate-certainty evidence
0.64(0.53–0.78)
P < 0.001Crystalloid vs No preloadI2 = 0%; very-low-certainty evidence
1.36(0.96–1.92)
P = 0.09Further pooled results
Postoperative complications
- No compelling data that these interventions reduced the risks of complications
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prevention of hypotension after neuraxial anesthesia in nonobstetric surgery: a systematic review. Can J Anaesth. Published 17 April 2025. doi:10.
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