Cardiothoracic & vascular anesthesia
A Multimodal Cardioprotection Strategy During Cardiac Surgery: The ProCCard Study
Authors' conclusion
This multimodal cardioprotection has not demonstrated any biological or clinical benefit during cardiac surgery.
Study context
- Population
- Patients scheduled for aortic valve surgery, multicentre tertiary care hospitals
- Participants
- 210 patients
- Comparison
- Multimodal cardioprotection vs standard of care
- Primary endpoint
- Postoperative AUC for high-sensitivity cardiac troponin I (hsTnI)
- Follow-up
- 72 h
Methodological detailsprospective, multicentre
- Prospective
- Multicentre
Primary result
As reported in the abstract
72-h AUC for hsTnI vs aortic clamping time
- Linear relationship between 72-h AUC for hsTnI and aortic clamping time significant in both groups
- p < 0.0001
- Relationship not modified by treatment
- p = 0.57
Secondary outcomes
72-h AUC for hsTnI when sevoflurane given during CPB (46% of Treated)
- Non-significant reduction
- −24%
- P
- P = 0.15
Postoperative renal failure
- Incidence not reduced
- P = 0.104
Safety
Adverse events · 30 days
- Rate identical in the two groups
Original publication
A Multimodal Cardioprotection Strategy During Cardiac Surgery: The ProCCard Study. J Cardiothorac Vasc Anesth. Published 14 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →