Cardiothoracic & vascular anesthesia
Impact of propofol or sevoflurane on the renoprotective effect of remote ischaemic preconditioning in cardiac surgery: the HypnoRenalRIP randomised clinical trial
Authors' conclusion
Transient increases in [TIMP-2]·[IGFBP7] induced by RIPC, which were associated with renoprotective effects, were only seen with sevoflurane anaesthesia, but not when propofol was used.
Study context
- Population
- High-risk patients undergoing cardiac surgery
- Participants
- 160 patients
- Comparison
- Propofol vs sevoflurane, each with remote ischaemic preconditioning (RIPC) or sham-RIPC
- propofol+sham-RIPCn = 20
- propofol+RIPCn = 60
- sevoflurane+sham-RIPCn = 20
- sevoflurane+RIPCn = 60
- Primary endpoint
- Change in urinary [TIMP-2]·[IGFBP7] from before to after the intervention
Methodological detailssingle-centre, prospective, double-blind, 2×2 factorial
- Single-centre
- Prospective
- Double-blind
- 2×2 factorial
Primary result
As reported in the abstract
Median change in [TIMP-2]·[IGFBP7] (response to RIPC), by anaesthetic
Sevoflurane
0.070
median · IQR −0.120–0.418
Propofol
−0.015
median · IQR −0.138–0.068
P = 0.022
Further findings
Elevated [TIMP-2]·[IGFBP7] as renal stress in response to surgery
- Detected in all groups except sevoflurane+RIPC
- P = 0.001
Patient-centred outcomes
- No statistically significant differences between groups
Original publication
Impact of propofol or sevoflurane on the renoprotective effect of remote ischaemic preconditioning in cardiac surgery: the HypnoRenalRIP randomised clinical trial. Br J Anaesth. Published 14 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →