Cardiothoracic & vascular anesthesia
Effects of remote ischaemic preconditioning against acute kidney injury in cardiac surgery patients: a randomized controlled trial
Authors' conclusion
In this trial, RIPC reduced the proportion of AKI and the amplitude of SCr elevation 48 h postoperatively.
Study context
- Population
- Patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB)159 completed follow-up
- Participants
- 180 patients
- Comparison
- Remote ischaemic preconditioning (RIPC) vs control
- RIPCn = 80
- Control (Con)n = 79reference
- Primary endpoint
- Proportion of acute kidney injury (AKI)
- Follow-up
- 48 h after surgery
Methodological detailssingle-centre, prospective, double-blind
- Single-centre
- Prospective
- Double-blind
Primary result
As reported in the abstract
AKI
P = 0.044
Secondary outcomes
Serum creatinine (SCr) · 24 h postoperatively
P = 0.035
Serum creatinine (SCr) · 48 h postoperatively
P = 0.004
| Outcome | P value |
|---|---|
| Urinary IGFBP7 · postoperativeLower in RIPC | P = 0.045 |
| Urinary IGFBP7×TIMP-2 · postoperativeLower in RIPC | 0.009 |
Short-term outcomes
- No significant differences in short-term outcomes
Safety
- No significant differences in postoperative complications
Original publication
Effects of remote ischaemic preconditioning against acute kidney injury in cardiac surgery patients: a randomized controlled trial. Perioper Med (Lond). Published 17 December 2025. doi:10.
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