Respiratory failure & ventilation
Profiling Bacteria in the Lungs of Patients with Severe Influenza Versus coronavirus disease (COVID-19) with or without Aspergillosis
Authors' conclusion
Aspergillosis is more frequently detected in the lungs of patients with severe influenza than bacterial pathogens. Detection of bacterial pathogens associates with worse outcome in patients with influenza, particularly in those with IAPA, but not in patients with COVID-19.
Study context
- Population
- Mechanically ventilated patients with influenza or COVID-19, with or without invasive aspergillosis, with BAL for bacterial culture within 2 weeks after ICU admission
- Participants
- 142 vs 281
- Exposure
- Severe influenza vs COVID-19, with or without aspergillosis
- Influenzan = 142
- COVID-19n = 281
- Outcome
- Potential bacterial pathogens and aspergillosis detected in BAL
Methodological details16S rRNA gene sequencing subset analysis
- 16S rRNA gene sequencing subset analysis
Main finding
As reported in the abstract
| Group | Value | Aspergillosis |
|---|---|---|
| Influenza | 20% | 38% (54/142) |
| COVID-19 | 37% | 31% (86/281) |
Value
Influenza20%
COVID-1937%
Aspergillosis
Influenza38% (54/142)
COVID-1931% (86/281)
Observational data: associations, not effects.
Further findings
Association of bacterial pathogens in BAL with 90-day mortality
- Significant association only in influenza, particularly influenza-associated pulmonary aspergillosis (IAPA)
Proinflammatory pulmonary cytokine responses to bacterial pathogens
- Increased in COVID-19, not in influenza
Original publication
Profiling Bacteria in the Lungs of Patients with Severe Influenza Versus COVID-19 with or without Aspergillosis. Am J Respir Crit Care Med. Published 15 November 2024. doi:10.
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