Prognosis of liver abscess in the intensive care unit (POLAIR), a multicentre observational study
Authors' conclusion
This multicentre study illustrates the severity of LA in French intensive care units and identifies organ dysfunction (SOFA score) and portal vein thrombosis as major risk factors for mortality.
Study context
- Population
- Adults with liver abscess admitted to 24 intensive care unit (ICUs) in France, 2010–2020
- Participants
- 335 adults · 24 ICUs
- Outcome
- Risk factors for mortality
Methodological detailsmulticentre, propensity score adjustment
- Multicentre
- Propensity score adjustment
Main finding
As reported in the abstract
Risk factors for mortality (multivariate analysis)
Hazard ratio (CI)P value
SOFA score (organ dysfunction)
3.45(1.95–6.09)
P < 0.001PVT
3.14(1.54–6.39)
P = 0.001Drainagenot associated with improved short-term survival
1.22(0.65–2.72)
P = 0.52Observational data: associations, not effects.
Further findings
Risk factors for mortality, population matched for portal vein thrombosis (PVT) confounders
| HR (IC95% CI) | P value | ||
|---|---|---|---|
| Higher SOFA scoreOnly factor associated with mortality · propensity score matched | 3.11 (1.76–5.49) | P = 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
In-ICU mortality
- In-ICU mortality
- 11.6%
Patient characteristics and management
- Median age, years [IQR]
- 66 [53-73]
- Male
- 68%
- Diabetes
- 29.9%
- Septic shock as main reason for admission
- 58%
- Median SAPS2 at ICU admission
- 42 [31-53]
- SOFA score
- 6 [3-9]
- Biliary origin
- 31%
- Cryptogenic
- 40%
- Solitary liver abscess (LA)
- 60%
- Right lobe
- 38.8%
- Median diameter, mm
- 67 [47-91]
- PVT
- 13.4%
- Microbiological documentation
- 82%
- Gram-negative bacilli
- 59.7%
- Escherichia coli
- 19.6%
- Klebsiella spp.
- 19.1%
- Gram-positive cocci
- 29.6%
- Streptococcus spp.
- 17.1%
- Drainage performed
- 62%
- Drainage within 48 h
- 40%
- Median antibiotic duration, days
- 35 [21-42]
- Vasopressors required
- 62%
- Mechanical ventilation required
- 29%
Original publication
Prognosis of liver abscess in the intensive care unit (POLAIR), a multicentre observational study. Crit Care. Published 7 April 2025. doi:10.
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