Prolonged versus intermittent β-lactam infusion in sepsis: a systematic review and meta-analysis of randomized controlled trials
Pooled result · All-cause mortalityResult — go to the resultRelative risk 0.83 95% CI 0.72–0.97Authors' conclusion
Compared to intermittent infusion, prolonged infusion of β-lactam antibiotics significantly decreases all-cause mortality among patients with sepsis and enhances clinical success without increasing adverse events.
Study context
- Population
- Adults with sepsis
- Participants
- 2,130 adults · 15 studies
- Comparison
- Prolonged vs intermittent β-lactam infusion
- Outcome
- All-cause mortality
Methodological detailsrandom-effects model, subgroup analyses
- Random-effects model
- Subgroup analyses
Pooled result
As reported in the abstract
Relative risk
0.83
95% CI 0.72–0.97
P = 0.02
Further pooled results
All-cause mortality, studies with >20 individuals per group (subgroup)
- Subgroup: studies with sample sizes exceeding 20 individuals per group
- RR, 0.84; 95%CI 0.72-0.98; P = 0.03
All-cause mortality, research conducted post-2010 (subgroup)
- Subgroup: research conducted post-2010
- RR, 0.84; 95%CI 0.72-0.98; P = 0.03
All-cause mortality, infections predominantly Gram-negative (subgroup)
- Subgroup: infections predominantly caused by Gram-negative bacteria
- RR, 0.81; 95%CI 0.68-0.96; P = 0.02
All-cause mortality, loading dose (subgroup)
- Subgroup: administration of a loading dose
- RR, 0.84; 95% CI 0.72-0.97; P = 0.02
All-cause mortality, penicillin (subgroup)
- Subgroup: use of penicillin
- RR, 0.61; 95% CI 0.38-0.98; P = 0.04
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Adverse eventsNo significant differences | 0.91 (0.64–1.29) | P = 0.60 | |
| 0.512Relative risk (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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