Propofol and survival: an updated meta-analysis of randomized clinical trials
Pooled resultResult — go to the resultRelative risk 1.10 95% CI 1.01–1.20Authors' conclusion
Propofol may reduce survival in perioperative and critically ill patients.
Study context
- Population
- Patients in any clinical setting (perioperative and critically ill)
- Participants
- 30,757 patients · 252 RCTs
- Comparison
- Propofol vs any other hypnotic agent or comparator
- Propofoln = 14,754
- Comparatorn = 16,003reference
- Outcome
- Mortality at the longest follow-up available
- Follow-up
- Longest available
Methodological detailsfixed-effects, Bayesian analysis
- Fixed-effects
- Bayesian analysis
Pooled result
As reported in the abstract
Relative risk
1.10
95% CI 1.01–1.20
P = 0.03
Events by group
Propofol vs Comparator
RR 1.10 (95% CI 1.01–1.20); P = 0.03
- Probability of any increase in mortality
- 98.4%
Further pooled results
- Significant mortality increase with propofol confirmed in subgroups of cardiac surgery, adults, volatile agent as comparator, large studies, and studies with low comparator mortality
Original publication
Propofol and survival: an updated meta-analysis of randomized clinical trials. Crit Care. Published 12 April 2023. doi:10.
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