Prospective evaluation of bleeding risk among thrombocytopenic patients admitted in intensive care unit
Authors' conclusion
Plasma urea levels and the presence of skin purpura are helpful in identifying thrombocytopenic patients at high-risk of bleeding during ICU stay.
Study context
- Population
- Consecutive medical ICU patients with thrombocytopenia (<150 Giga/L) and no bleeding at admissionover one year
- Participants
- 91 patients
- Exposure
- Bleeding vs No-Bleeding during ICU stay
- Bleedingn = 23
- Outcome
- Hemorrhagic event during ICU stay
Methodological detailssingle-centre, 18-bed medical ICU, consecutive patients
- Single-centre
- 18-bed medical ICU
- Consecutive patients
Main finding
As reported in the abstract
Patients with a hemorrhagic event during ICU stay
23
25%
Digestive bleeding
n = 9; 39%
Urological bleeding
n = 6; 26%
Time from ICU admission to bleeding, days (median [IQR])
8
2–19
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | P value | |
|---|---|---|---|
| Skin purpura at admission and bleeding riskSkin purpura vs No skin purpura · 3-fold higher risk for bleeding during ICU stay | 3.4 (1.3–8.3) | P < 0.05 | |
| 0.10.31310Hazard ratio (log scale) |
Plasma urea at admission
- Significantly higher in the Bleeding group (as printed: 9 [5.1; 13] vs. 13 [8.9; 31] mmol/L)
- P < 0.001
Platelet count at admission
- Not significantly different between the 2 groups (90 [32; 128] vs 62 [36; 103] G/L)
- P = 0.26
Severity of bleeding events
- Almost half of bleeding events required vasopressor infusion and a hemostatic procedure
Original publication
Prospective evaluation of bleeding risk among thrombocytopenic patients admitted in intensive care unit. J Crit Care. Published 31 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →