Psychomotor Responses to Independent Visual, Auditory and Tactile Electrical stimuli during Sevoflurane sedation (PRIVATES)
Authors' conclusion
Patient-controlled sevoflurane sedation is potentially feasible in a healthy population within the dose range 0.4-1.2 kPa.
Study context
- Population
- Healthy participants receiving sevoflurane sedation10 males
- Participants
- 15 participants
- Outcome
- Relationship between sedation, psychomotor function and adverse effect occurrence (sevoflurane dose at RASS <0, at inability to complete reaction time testing, and at protocol endpoint)
Methodological detailsclinician-controlled sevoflurane sedation, single group, Dose escalation from 0 kPa in 0.2 kPa increments until protocol endpoint (airway, respiratory or cardiovascular compromise; agitation Richmond Agitation-Sedation Scale (RASS) ≥+2; sedation >3 h)
- Clinician-controlled sevoflurane sedation
- Single group
- Dose escalation from 0 kPa in 0.2 kPa increments until protocol endpoint (airway, respiratory or cardiovascular compromise; agitation RASS ≥+2; sedation >3 h)
Main finding
As reported in the abstract
Sevoflurane dose
- Sedation dose (RASS <0), median [range]
- 0.4 [0.2-1.0] kPa
- Button-press dose (unable to complete reaction time testing), median [range]
- 1.2 [0.6-2.0] kPa
- Endpoint dose (protocol endpoint), median [range]
- 1.6 [1.2-2.2] kPa
- Sedation dose less than button-press dose
- P<0.0001
- Button-press dose less than endpoint dose
- P=0.002
Safety
Protocol endpoint reached
- Sedation >3 h
- 9 (60%)
- Agitation
- 5 (33%)
- Tonic movements
- 1 (7%)
Original publication
Psychomotor Responses to Independent Visual, Auditory and Tactile Electrical stimuli during Sevoflurane sedation (PRIVATES). Br J Anaesth. Published 19 March 2025. doi:10.
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